Prognostic impact of the cumulative dose and dose intensity of everolimus in patients with pancreatic neuroendocrine tumors (PNETs)

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Prognostic impact of the cumulative dose and dose intensity of everolimus in patients with pancreatic neuroendocrine tumors

The aim of this work is to assess if cumulative dose (CD) and dose intensity (DI) of everolimus may affect survival of advanced pancreatic neuroendocrine tumors (PNETs) patients. One hundred and sixteen patients (62 males and 54 females, median age 55 years) with advanced PNETs were treated with everolimus for ≥3 months. According to a Receiver operating characteristics (ROC) analysis, patients...

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Etiological Observations in Seven Patients with Pancreatic Neuroendocrine Tumors (PNETs).

BACKGROUND/AIM Pancreatic neuroendocrine tumors (PNETs) are uncommon malignancies of largely unknown pathogenesis. Observations on patients and their families can provide clues on etiology. PATIENTS AND METHODS In a medical oncology practice cohort of 2,087 patients 5 females and 2 males with PNETs have been identified. RESULTS Observations of etiologic interest have been made in 2 patients...

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Diagnostic protocol for pancreatic neuroendocrine tumors (PNETs).

A: angiography; US: ultrasonography; EUS: endoscopic ultrasonography; IUS: intraoperative ultrasonography; EUS-FNA: endoscopic ultrasonography-guided fine-needle aspiration; MRI: magnetic resonance imaging; SRS: octreoscan; CT: computerized tomography; MDCT: multidetector computerized tomography; PET: positron emission tomography; PET-CT: PET with computerized tomography; ICC: immunocytochemist...

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Behavior of Small, Asymptomatic, Nonfunctioning Pancreatic Neuroendocrine Tumors (NF-PNETs)

Small nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs) usually exhibit minimal or no growth over many years. However, there is a controversy regarding the optimal management of incidentally discovered, small NF-PNETs. This study aimed to gain insights into tumor behavior and potential strategies for clinical management.We retrospectively reviewed a total of 202 patients with a suspect...

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ژورنال

عنوان ژورنال: Annals of Oncology

سال: 2016

ISSN: 0923-7534

DOI: 10.1093/annonc/mdw369.28